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GemPharmatech

GemPharmatech

Rodents Model Model Generation Mouse Strain data Base
Disease Mice Immunedeficient Mice Humanized Mice
  • Apoe
Strain Name B6/JGpt-Apoeem1Cd82/Gpt Application

1.Cardiovascular disease research
2.Hypercholesterolemia research
Strain Type knockout    CRISPR/Cas9 
Strain ID T001458 
Backgrounde C57BL/6JGpt
  • Ldlr
Strain Name B6/JGpt-Ldlrem1Cd82/Gpt Application

1.Cardiovascular disease research
2. Efficacy evaluation of vascular drugs
Strain Type knockout    CRISPR/Cas9 
Strain ID T001464
Backgrounde C57BLKS/JNju
  • BKS-DB
Strain Name BKS-Leprem2Cd479/Gpt Application

1. Study of Diabetes Type2
2. Metabolism research
Strain Type knockout    CRISPR/Cas9 
Strain ID T002407
Backgrounde C57BLKS/JNju
  • B6-OB
Strain Name B6/JGpt-Lepem1Cd25/Gpt Application

1. Study of obesity
2. Lpetin protein deficient research
Strain Type knockout    CRISPR/Cas9
Strain ID T001461
Backgrounde C57BL/6JGpt
  • DIO
Strain Name C57BL/6JGpt DIO 60% Application

1. Diet induced Obesity model
Strain Type Inbred
Strain ID T002040
Backgrounde C57BL/6JGpt
  • NOD
Strain Name NOD/ShiLtJGpt Application

1. IDDM (insulin dependent diabetes mellitus) research
2. Metaboism research
Strain Type Inbred
Strain ID N000235
Backgrounde NOD/ShiLtJGpt
  • BALB/c-nu
Strain Name BALB/cJGpt-Foxn1nu/Gpt Application

1. Dermatologic study2. Endocrine deficiency research
3. Xenograft, Cancer research
4. Immune, inflammation research
Strain Type Mutation
Strain ID D000521
Backgrounde BALB/cJGpt
  • NOD SCID
Strain Name NOD/ShiLtJGpt-Prkdcem26Cd52/Gpt Application

1. Type I Diabetes, Obesity research2. Immune, Inflammatory study
3. Immune defects, Internal organ research
4. Cancer research
Strain Type Cas9-KO
Strain ID T001492
Backgrounde NOD/ShiLtJGpt
  • NCG
Strain Name NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt Application

1. Human innune system reconstitution2. Preclinical anti-tumor efficacy study with CDX,PDX
3. Immuno-oncology therapy research
4. Stem cell research
Strain Type Knock-out
Strain ID T001475
Backgrounde NOD/ShiLtJGpt
  • NCG-Hairless
Strain Name NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22Hrem1Cin8936/Gpt Application

1. Research of humanized mouse models2. CDX, PDX
3. Human cancer, hematopoietic system, immune system model
4. Stem cell research
Strain Type knock-in
Strain ID T003257
Backgrounde NOD/ShiLtJGpt
  • NCG-B2m-KO
Strain Name NOD/ShiLtJGpt-B2Mem21Cd4Prkdcem26Cd52Il2rgem26Cd22/Gpt Application

1. Human immune system reconstitution2. Human tumor transplantation
3. Human hematopoietic, immune system research
4. Graft versus host disease (GVHD)
Strain Type knock-out
Strain ID T004670
Backgrounde NOD/ShiLtJGpt
  • NCG-HLA-A2.1
Strain Name NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22H2-K1emCin(HLA-A2.1)/Gpt Application

1. Vaccine research2. Hematopoietic stem cell transplantation
3. Establish the humanized immune system
4. Immune system research
Strain Type knock-in
Strain ID T003278
Backgrounde NOD/ShiLtJGpt

CD3e

  • BALB/c-hCD3E
Strain Name BALB/cJGpt-Tg(hCD3E)102/Gpt Application

1. Study on the development and activation of T cell
2. T cell bispecific antibody screening
Strain Type Transgene
Strain ID T001550
Backgrounde BALB/cJGpt

PD-1/PD-L1

  • BALB/c-hPDL1
Strain Name BALB/cJGpt-Cd274em1Cin(hCD274)/Gpt Application

1. Efficacy evaluation of human PDL1 inhibitors
2. Assessment of human PDL1 inhibitor safety
3. Research on immune system
Strain Type knock-in CRISPR/Cas9
Strain ID T003260
Backgrounde BALB/cJGpt
  • B6-hPDL1
Strain Name B6/JGpt-Cd274tm1(hCD274)/Gpt Application

1. Efficacy evaluation of human PDL1 inhibitors
2. Safety evaluation of human PDL1 inhibitors
3. Anticancer Drug Research and Development
4. Research on autoimmune diseases
Strain Type knock-in ES
Strain ID T003455
Backgrounde C57BL/6JGpt
  • BALB/c-hPD1
Strain Name BALB/cJGpt-Pdcd1em1Cin(hPDCD1)/ Gpt Application

1. Efficacy evaluation of human PD1 inhibitors
2. Assessment of human PD1 inhibitor safety
3. Research on immune system
Strain Type knock-in CRISPR/Cas9
Strain ID T002726
Backgrounde BALB/cJGpt
  • B6-hPD1
Strain Name B6/JGpt-Pdcd1em1Cin(hPDCD1)/Gpt Application

1. Efficacy evaluation of human PD1 inhibitors
2. Assessment of human PD1 inhibitor safety
3. Research on immune system
Strain Type knock-in CRISPR/Cas9
Strain ID T003095
Backgrounde C57BL/6JGpt

TIGIT

  • BALB/c-hPD1/hTIGIT
Strain Name BALB/cJGpt-Pdcd1 em1Cin(hPDCD1) Tigit em1Cin(hTIGIT) /Gpt Application

1. Screening of human TIGIT inhibitors or human PD1 inhibitors
2. Evaluation of efficacy and safety of human TIGIT inhibitorcombine with human PD1 inhibitor
3. Research on immune system
Strain Type Knock-in
Strain ID T004023
Backgrounde BALB/cJGpt
  • B6-hPD1/hTIGIT
Strain Name B6/JGpt-Pdcd1 em1Cin(hPDCD1) Tigit em1Cin(hTIGIT) /Gpt Application

1. Screening of human TIGIT inhibitors or human PD1 inhibitors
2. Evaluation of efficacy and safety of human TIGIT inhibitors combine with human PD1 inhibitor
3. Research on immune system
Strain Type Knock-in
Strain ID T004024
Backgrounde C57BL/6JGpt
  • BALB/c-hTIGIT
Strain Name BALB/cJGpt-Tigit em1Cin(hTIGIT) /Gpt Application

1. Efficacy evaluation of human TIGIT inhibitors
2. Safety assessment of human TIGIT inhibitors
3. Research on immune system
Strain Type Knock-in
Strain ID T003365
Backgrounde BALB/cJGpt
  • B6-hTIGIT
Strain Name B6/JGpt-Tigit em1Cin(hTIGIT) /Gpt Application

1. Efficacy evaluation of human TIGIT inhibitors
2. Safety assessment of human TIGIT inhibitors
3. Research on immune system
Strain Type Knock-in
Strain ID T003366
Backgrounde C57BL/6JGpt

CTLA-4

  • BALB/c-hCTLA4
Strain Name BALB/cJGpt -Ctla4 em1Cin(hCTLA4) /Gpt Application

1. Efficacy evaluation of human CTLA4 inhibitor
2. Toxicological evaluation of human CTLA4 inhibitor
3. Screening of human CTLA4 agonist
Strain Type Knock-in
Strain ID  T003361
Backgrounde BALB/cJGpt
  • B6-hPD1/hCTLA4
Strain Name B6/JGpt-Pdcd1 em1Cin(hPDCD1) Ctla4 em1Cin(hCTLA4) /Gpt Application

1. Efficacy evaluation of human CTLA4,PD1 inhibitor
2. Combo pharmaceutical efficacy evaluation of CTLA4 and PD1 inhibitor;
3. Toxicological evaluation of human CTLA4 inhibitor and human PD1 inhibitor;
4. Research and Development of anti-cancer mechanism;
Strain Type Knock-in
Strain ID  T003826
Backgrounde C57BL/6JGpt
  • BALB/c-hCTLA4
Strain Name  BALB/cJGpt -Ctla4 em1Cin(hCTLA4) /Gpt Application

1. Efficacy evaluation of human CTLA4 inhibitor
2. Toxicological evaluation of human CTLA4 inhibitor
3. Screening of human CTLA4 agonis
Strain Type Knock-in
Strain ID T003361
Backgrounde BALB/cJGpt
  • B6-hCTLA4
Strain Name  B6/JGpt-Ctla4 em1Cin(hCTLA4) /Gpt Application

1. Efficacy evaluation of human CTLA4 inhibitor
2. Toxicological evaluation of human CTLA4 inhibitor
3. Screening of human CTLA4 agonist
Strain Type Knock-in
Strain ID T003362
Backgrounde C57BL/6JGpt

CD137

  • BALB/c-hCD137
Strain Name BALB/cJGpt-Tnfrsf9 em1Cin(hTNFRSF9) /Gpt Application

1. Efficacy evaluation of human CD137 agonist
2. Assessment of human CD137 agonist safety
3. Research on immune system
Strain Type Knock-in
Strain ID T003359
Backgrounde BALB/cJGpt
  • B6-hCD137
Strain Name B6/JGpt-Tnfrsf9 em1Cin(hTNFRSF9) /Gpt Application

1. Efficacy evaluation of human CD137 agonist
2. Safety Assessment of human CD137 agonist
3. Research on immune system
Strain Type Knock-in
Strain ID T003360
Backgrounde C57BL/6JGpt

OX40

  • BALB/c-hPD1/hOX40
Strain Name BALB/cJGpt-Pdcd1 em1Cin(hPDCD1) Tnfrsf4 em1Cin(hTNFRSF4) /Gpt Application

1. Screening of human OX40 agonists or human PD1 inhibitors
2. Evaluation of efficacy, safety of OX40 agonist combine with PD1 inhibitor
Strain Type Knock-in
Strain ID T003804
Backgrounde BALB/cJGpt
  • B6-hOX40
Strain Name B6/JGpt-Tnfrsf4 em1Cin(hTNFRSF4) /Gpt Application

1. Screening of human OX40 agonist and inhibitor
2. OX40-related drug efficacy evaluation
3. Anti-tumor research
4. Autoimmune disease research
Strain Type Knock-in
Strain ID T002140
Backgrounde C57BL/6JGpt

LAG3

  • B6-hPD1/hLAG3
Strain Name  B6/JGpt-Pdcd1 em1Cin(hPDCD1) Lag3 emCin(hLAG3) /Gpt Application

1. Evaluation of efficacy and safety of human LAG3 inhibitors
2. Evaluation of the combined efficacy LAG3, PD1 inhibitor
3. Anti-tumor Drug Research and Development
4. Research on autoimmune diseases
Strain Type Knock-in
Strain ID T004621
Backgrounde C57BL/6JGpt
  • B6-hLAG3
Strain Name  B6/JGpt-Lag3 emCin(hLAG3) /Gpt Application

1. Efficacy evaluation of human LAG3 inhibitors
2. Safety evaluation of human LAG3 inhibitors
3. Anti-tumor Drug Research and Development
4. Research on autoimmune diseases
Strain Type Knock-in
Strain ID T003597
Backgrounde C57BL/6JGpt

TIM3

  • BALB/c-hPD1/hTIM3
Strain Name BALB/cJGpt- Pdcd1 em1Cin(hPDCD1) Havcr2 tm1(hHAVCR2) / Gpt Application

1. Efficacy evaluation of human TIM3 inhibitor
2. Safety evaluation of human TIM3 inhibitor
3. Research on anti-tumor and autoimmune diseases
Strain Type Knock-in
Strain ID T004795
Backgrounde BALB/cJGpt

CD47/SIRPa

CD28

BTLA

CD27

GITRa

  • CRISPR/Cas9 Technology
CRISPR/Cas9 is the most common gene editiong technology currently which can be used to establish gene-edited mice including CKO/KO/KI/PM.
Advantages
  • 1. High quality Executing the most stringent quality control standards, Realtime PCR detection, 0 random insertion, 0 serial recombination
  • 2. High efficiency GPTech optimized efficient gene editing platform, higher success rate and shorter delivery cycle
  • 3. Multi-modification Multiple loci or multiple genes of the target gene were knocked out at the same time, and the ultra-long target fragment 23Mbps was successfully KO
  • 4. Multi-background C57BL/6J, C57BL/6N, BALB/C, FVB, FVB, NOD/LTJ, NCG, etc.
  • ES HR Technology
ES Homologous Recombination(HR) Technology for obtaining gene-edited mouse models is more suitable for establishing mouse models with complex editing
Advantages
  • 1. Self-deletion of resistance genes Saving 3 months modeling time
  • 2. BAC shooting technology Achieving 100-300kb large segment knock-in
  • 3. Rich experience in model establishmen Producing the first domestic CKO model in 2005; from then on, more than 700 ES target models have been successfully completed.
  • 4. Multi-background 129S6/SvEvTac, C57BL/6N
  • Transgenic Technology
Obtained Genetic engineering mouse models by random integration of DNA into the mouse genome is generally used for the establishment of overexpressed or conditioned overexpressed mice.
Advantages
  • 1.BAC transgenic technology to achieve a transgenic model of 100-300kb or more
    2.Multiple background selection C57BL/6J, C57BL/6N, BALB/C, FVB, FVB, NOD/LTJ, NCG, etc.
  • Gempharmatech Mouse Stain Data Base
Gempharmatech은 약10,000여종의 mouse strain을 보유하고 있습니다.
Stain 또는 Gene 으로 찾아보실수 있습니다.