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SMOC

U-GEMMs

The establishment of U-GEMM (yoUr Genetically Engineered Mouse Model) repository containing 6,000+ “off-shelf” proprietary sets the stage of entry into new possibilities in gene function, drug screening, and human disease research.

- Toolbox of Mice

  • Find Cre
  • Reporters
  • CRISPR/Cas knockins
  • Tet-regulated

- Disease Mice

  • Spontaneous Tumor
  • Rare Disease
  • Infectious Disease
  • Nervous System Disease
  • Cardio-metabolic Disease
  • Autoimmune Disease

- Immune-Related Mice

  • Humanized Drug Targets
  • Immunodeficient
  • Cytokine Reporters
  • Inducible Cell Ablation
  • Cell-specific Reporters

- Standard GEMMs

  • Knockouts
  • Conditional Knockouts
  • Regular Transgenics
  • Point Mutation Knockins
  • Regular Knockins
  • Humanized Knockins

Rats

We offer several research-ready rat models to jump start your rat experiments. Browse the strain list by application, or directly search for the strain of your interest.

  • Humanized Drug Targets
  • Immunodeficient
  • Diseases
  • Reporters
  • Cre-drivers

Cells

SMOC reserves over 100 commonly used tumor cell lines, mostly derived from the ATCC and the Chinese Academy of Sciences Collection Committee cell bank. These cell lines can be used to offer technical services such as cell line knock-in/knock-out, cell proliferation/apoptosis, and cell migration/invasion.

  • Reporter-labeled
  • Primary
  • Humanized Drug Targets
  • Wild-type
  • Others

Standard Strains

Balb/c, Balb/c-nude, C57bl/6, ICR, NOD SCID

  • Inbred
  • Outbred

Model Customization

Since its establishment in September 2000, Shanghai Model Organisms Center (SMOC) strives to be the best-in-class resource center for biomedical researchers and industry partners, with its highly efficient and reliable technology platform.

  • Model Customization
  • Gene Editing Technology
  • Genetically Engineered Type
  • Surgery & Preconditioning

Therapeutic Area

  • Oncology
  • Nervous System Disease
  • Autoimmune Disease
  • Digestive System Disease
  • Metabolic Disease

Preclinical Services

blood cell and blood biochemical testing, CT image analysis, pathological section and immunohistochemical analysis, FACS sorting and analysis, detection of blood cytokines, gene expression and protein analysis, whole-body in vivo imaging and analysis, metabolic analysis, behavioral research.

  • Non-GLP Toxicology
  • Pharmacokinetics
  • Phenotype Analysis
  • Pharmacology & Pharmacodynamics

SMOC Strain Data Base

SMOC core competencies

- 21 years of experience in animal models
- A complete range of animal model services
- A wide selection of animal models
- Over 6000 available off-the-shelf mouse models for your selection
- More than 11000 genetically-engineered mouse models established
- A complete range of animal model services
- Model customization
- Research-ready models
- Breeding
- Phenotyping
- Drug screening

SMOC Received OLAW (Office of Laboratory Animal Welfare) Approval for Animal Welfare Assurance Shanghai Model Organisms Center Inc.(SMOC) received the approval of Animal Welfare Assurance from the Office of Laboratory Animal Welfare (OLAW) of the U.S. National Institutes of Health (NIH) for its animal facility on January 25, 2021.